Symptoms usually appear after a person stops using the drugs, especially if they do so abruptly.Ĭhanges in hormone levels usually happen over time, and a person may not notice any difference. This leads to a reduction in a type of steroid known as glucocorticoid. Secondary adrenal deficiency can also develop when a person uses steroid drugs that affect the hypothalamus and the pituitary gland and prevent the body from producing ACTH. genetic conditions that affect the pituitary gland. Other causes of secondary adrenal insufficiency include: Consequently, the adrenal glands will also produce lower levels of hormones. Issues with the pituitary glands can cause them to produce less ACTH. The pituitary gland produces adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce other hormones. Indirectly, issues with the pituitary gland can cause Addison’s disease.
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